2026-09-11 カリフォルニア大学バークレー校（UCB）
In healthy older study participants, PET scans revealed the protein tau building up over time in their frontal cortices. This buildup correlates with shortened, isolated slow brain waves during sleep and with memory loss. Courtesy of Omer Sharon/UC Berkeley Department of Psychology
＜関連情報＞
- https://news.berkeley.edu/2026/09/11/new-uc-berkeley-study-links-deep-sleep-loss-to-alzheimers-related-protein-buildup/
- https://www.nature.com/articles/s41593-026-02415-9
ヒトのタウ病理は、記憶障害に関連する孤立した非伝播性の徐波と関連している Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment
Omer Sharon,Xi Chen,Jason Dude,James Westphal,Chelsea Brown,Vyoma D. Shah,Yo-El S. Ju,William J. Jagust & Matthew P. Walker
Nature Neuroscience Published:11 September 2026
DOI:https://doi.org/10.1038/s41593-026-02415-9
Abstract
Memory markedly declines with age, exaggerated in those with Alzheimer’s disease, yet the mechanisms are still not resolved. Here we show that frontal lobe tau pathology in humans is associated with impaired en masse unity and cortical traveling propagation of nonrapid eye movement slow waves, linked to impaired memory retention. We elucidate these findings using positron-emission tomography tau brain imaging, and then replicate and extend them using Alzheimer’s disease pathology markers derived from cerebrospinal fluid in an independent clinical cohort. Thus, tau-associated memory deficits are not wholly direct but indirectly linked to consequential ‘lonely’, nontraveling slow-wave events.
