2026-10-07 カロリンスカ研究所（KI）
＜関連情報＞
- https://news.ki.se/low-family-income-during-childhood-is-linked-to-atherosclerosis-later-in-life
- https://www.ahajournals.org/doi/10.1161/JAHA.126.050332
幼少期の親の低所得は、中年期の冠動脈アテローム性動脈硬化症と関連している Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife
Sebastian Herlitz, MD, Agnes Wahrenberg, MD, PhD, Henrike Häbel, PhD, Göran Bergström, MD, PhD, Gunnar Engström, MD, PhD, Emil Hagström, MD, PhD, Tomas Jernberg, MD, PhD, Lars Lind, MD, PhD, Stefan Söderberg, MD, PhD, Carl Johan Östgren, MD, PhD, Joel Ohm, MD, PhD, and Per Svensson, MD, PhD
Journal of the American Heart Association Published: 7 October 2026
DOI:https://doi.org/10.1161/JAHA.126.050332
Abstract
Background
Socioeconomic status (SES) is a major risk factor for coronary heart disease, but the life‐course mechanisms and causal pathways remain poorly understood. Therefore, we investigated whether low childhood SES was associated with midlife coronary atherosclerosis and if any association could be explained by established risk factors in adulthood.
Methods
This observational cohort study included 15 640 participants, aged 50 to 64 years, from the population‐based SCAPIS (Swedish Cardiopulmonary Bioimage Study) who underwent coronary computed tomography angiography. Coronary atherosclerosis was assessed by segment involvement score and coronary artery calcification score. Childhood SES was defined by parental disposable income at participant age 10 to 12 years retrieved from national registers. Associations between moderate–severe coronary atherosclerosis (segment involvement score ≥4 or coronary artery calcification >100) and childhood SES were estimated using multivariable logistic regression adjusting for adult lifestyle habits, adult SES, and traditional cardiovascular risk factors.
Results
Participants in the lowest versus highest parental income quintile were more likely to have moderate–severe coronary atherosclerosis (segment involvement score ≥4; odds ratio [OR], 1.43 [95% CI, 1.20–1.71], P<0.001). The association persisted after adjustment for adult lifestyle habits (OR, 1.42 [95% CI, 1.17–1.73], P<0.001), adult SES (OR, 1.31 [95% CI, 1.09–1.57], P=0.004), traditional cardiovascular risk factors (OR, 1.28 [95% CI, 1.06–1.53], P=0.008), and full adjustment (OR, 1.31 [95% CI, 1.07–1.61], P=0.010). Similar associations were observed for coronary artery calcification >100.
Conclusions
Low childhood SES was associated with moderate–severe coronary atherosclerosis in midlife only partially explained by established risk factors in adulthood. Our findings suggest that childhood SES is a social determinant of long‐term cardiovascular health that cannot be fully explained by established adult risk factors.
