2026-10-08 理化学研究所,東京都立大学
6種・複数の麻酔条件を共通の時系列特徴で比較
＜関連情報＞
- https://www.riken.jp/press/2026/20261008_1/index.html
- https://www.nature.com/articles/s41593-026-02460-4
系統発生全体にわたる麻酔中の脳ダイナミクスの包括的なプロファイリング Comprehensive profiling of brain dynamics during anesthesia across phylogeny
Andrea I. Luppi, Lynn Uhrig, Jordy Tasserie, Golia Shafiei, Antoine Légaré, Kanako Muta, Junichi Hata, Hideyuki Okano, Daniel Golkowski, Andreas Ranft, Rudiger Ilg, Denis Jordan, Silvia Gini, Zhen-Qi Liu, Yohan Yee, Pablo Castro, Camilo M. Signorelli, Rodrigo Cofre, Alain Destexhe, David K. Menon, Emmanuel A. Stamatakis, Patrick Desrosiers, Paul De Koninck, Christopher W. Connor, … Bratislav Misic
Nature Neuroscience Published:29 September 2026
DOI:https://doi.org/10.1038/s41593-026-02460-4
Abstract
The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, zebrafish and nematode. Applying massive feature extraction, we characterize local neural dynamics across >6,000 time-series features. This reveals a conserved dynamical profile of anesthesia across species, characterized by shorter intrinsic timescales of neural activity and dampened inter-regional synchrony. Deep-brain stimulation of the macaque centromedian thalamus reverses this profile and restores behavioral responsiveness. This conserved dynamical phenotype covaries with conserved transcriptional profiles of excitatory and inhibitory neurotransmission. Biophysical modeling provides a potential mechanistic link between the macroscale dynamical phenotype of anesthesia and microscale effects of key molecular targets on the timescales of synaptic excitation and inhibition. These analyses reveal a shared neural endpoint of anesthesia: across species and scales, anesthetics induce spatiotemporal isolation of local neural activity.
