2023-10-27 インペリアル・カレッジ・ロンドン(ICL)
◆この発見は、将来的にはアトピー性皮膚炎などの皮膚疾患の炎症におけるヒスタミンの役割を理解するのに役立つ可能性がある。研究は細胞培養で行われたもので、生きている生物で再現される必要があり、毛包が特定の種類の感覚神経を活性化するメカニズムが未だ解明されていない可能性がある。
<関連情報>
- https://www.imperial.ac.uk/news/248975/hidden-feel-touch-uncovered-imperial-researchers/
- https://www.science.org/doi/10.1126/sciadv.adh3273
ヒト毛包外毛根鞘培養物への機械的刺激は隣接する感覚ニューロンを活性化する Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons
Julià Agramunt,Brenna Parke,Sergio Mena,Victor Ubels,Francisco Jimenez,Greg Williams,Anna DY Rhodes,Summik Limbu,Melissa Hexter,Leigh Knight,Parastoo Hashemi,Andriy S. Kozlov,and Claire A. Higgins
Science Advances Published:27 Oct 2023
DOI:https://doi.org/10.1126/sciadv.adh3273
Abstract
Mechanical stimuli, such as stroking or pressing on the skin, activate mechanoreceptors transmitting information to the sensory nervous system and brain. It is well accepted that deflection of the hair fiber that occurs with a light breeze or touch directly activates the sensory neurons surrounding the hair follicle, facilitating transmission of mechanical information. Here, we hypothesized that hair follicle outer root sheath cells act as transducers of mechanical stimuli to sensory neurons surrounding the hair follicle. Using electrochemical analysis on human hair follicle preparations in vitro, we were able to show that outer root sheath cells release ATP and the neurotransmitters serotonin and histamine in response to mechanical stimulation. Using calcium imaging combined with pharmacology in a coculture of outer root sheath cells with sensory neurons, we found that the release of these three molecules from hair follicle cells leads to activation of sensory neurons.
