2025-03-18 ミシガン大学
<関連情報>
- https://news.umich.edu/abnormal-menstrual-bleeding-a-likely-culprit-in-menopausal-fatigue-rarely-discussed-as-cause/
- https://journals.lww.com/menopausejournal/abstract/9900/abnormal_uterine_bleeding_is_associated_with.438.aspx
子宮出血異常は更年期移行期の疲労と関連する Abnormal uterine bleeding is associated with fatigue during the menopause transition
Harlow, Siobán D. PhD; Gold, Ellen B. PhD; Hood, Michelle M. MSc; Mukwege, Alain A. MD, MSc; Randolph, John F. MD; Greendale, Gail A. MD
Menopause Published:March 11, 2025
DOI:10.1097/GME.0000000000002525
Abstract
Objective
During the menopause transition (MT), abnormal uterine bleeding, characterized by prolonged (PMB) or heavy (HMB) menstrual bleeding, occurs often. We assessed whether PMB or HMB was associated with fatigue.
Methods
We used longitudinal daily menstrual calendar data from 2,329 participants in the Study of Women’s Health Across the Nation to identify episodes of HMB and PMB. At seven annual follow-up visits, four symptoms of fatigue were queried (worn out, feeling tired, full of pep, having energy). General linear mixed models with random intercepts for each woman assessed the association between each fatigue variable and PMB or HMB recorded during the 6 months prior to each annual follow-up visit. Models were adjusted for race and ethnicity, age, body mass index, hormone therapy use, depressive and anxiety symptoms, perceived stress, sleep problems, cigarette use, and discrimination.
Results
After adjustment, reporting three or more episodes of HMB in the prior 6 months was positively associated with feeling tired (odds ratio [OR] = 1.62, 95% CI = 1.11 to 2.38) and being worn out (OR = 1.44, 95% CI = 0.98 to 2.13), whereas three or more episodes of PMB in the prior 6-month window was negatively associated with being full of pep (OR = 0.68, 95% CI = 0.49 to 0.95).
Conclusions
HMB and PMB during the MT were associated with increased odds of experiencing three symptoms of fatigue. Greater clinical attention to bleeding changes and associated symptoms, including fatigue and lack of energy, is warranted, as is education of women about potential health consequences of excessive menstrual bleeding during the MT.
