2026-04-21 東京科学大学
図1. 食品の継続摂取による歯肉の出血割合の変化
＜関連情報＞
- https://www.isct.ac.jp/ja/news/w4yrlx7j5yrn
- https://aap.onlinelibrary.wiley.com/doi/10.1002/jper.70141
熱失活させたLactiplantibacillus pentosus ONRICb0240含有ポストバイオティクスの摂取は歯肉の炎症を軽減する：二重盲検無作為化臨床試験 Consuming heat-inactivated Lactiplantibacillus pentosus ONRICb0240-containing postbiotics reduces gingival inflammation: A double-blind randomized clinical trial
Anhao Liu, Megumi Ishiguro, Yasuhiro Matsumura, Kyungtak Kwak, Seiichi Shimizu, Keiko Watabe, Hirotaka Nagashima, Shogo Maekawa, Takanori Iwata
Journal of Periodontology Published: 19 April 2026
DOI:https://doi.org/10.1002/jper.70141
Abstract
Background
Periodontal disease affects people globally, requiring approaches to halt progression at the gingivitis stage. Researchers have investigated live probiotics; we studied the effect of a heat-inactivated preparation (postbiotic) of Lactiplantibacillus pentosus ONRICb0240 on gingival inflammation.
Methods
A total of 116 participants with gingival inflammation but no periodontitis were randomized into groups administered placebo or postbiotic gummies containing heat-inactivated L. pentosus ONRICb0240 (b0240GC) twice daily for 6 weeks. The participants maintained their usual oral hygiene practices without additional instruction or treatment. The bleeding on probing percentage (BOP), probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque control record (PCR), and salivary volume were clinically assessed.
Results
BOP was the primary endpoint, significantly decreased in the b0240GC group (baseline vs. 6 weeks; 17.6 ± 8.4% vs. 12.3 ± 8.6%, p < 0.001) compared with that in the placebo group (18.9 ± 8.5% vs. 16.6 ± 10.1%, p = 0.344) in a sensitivity analysis excluding participants who used nonsteroidal anti-inflammatories. PPD, CAL, and PCR were the secondary endpoints that minimally changed, whereas the GI was significantly lower in the b0240GC group (baseline vs. 6 weeks: 1.3 ± 0.4 vs. 1.1 ± 0.6; p = 0.001) than in the placebo group (1.4 ± 0.4 vs. 1.3 ± 0.6). Exploratory post hoc subgroup analysis suggested stronger responses of BOP reduction in the b0240GC group among participants with a body mass index ≥22 kg/m2, a baseline BOP < 20%, or a PCR < 60%.
Conclusions
Continuously consuming b0240GC reduced gingival inflammation, excluding the influence of nonsteroidal anti-inflammatories, with no apparent safety concerns.
Trial Registration
ID number: jRCTs031220449; URL: https://jrct.mhlw.go.jp/en-latest-detail/jRCTs031220449
Plain language summary
Gum disease is also known as periodontal disease. Gum disease is common worldwide and can lead to tooth loss if not treated early. In the early gingivitis stages, the gums turn red and easily bleed. In addition to regular dental visits, simple methods must be developed for preventing the progression of gum disease, such as methods for safely reducing gum inflammation without disturbing the normal bacteria in the mouth. We tested whether eating gummy candies containing heat-inactivated bacteria (Lactiplantibacillus pentosus ONRICb0240) (b0240GC) improved gum health. We asked 116 adults with mild gum inflammation to eat either b0240GC or placebo gummies twice daily for 6 weeks. The participants did not receive any special instructions for brushing or cleaning their teeth during the study period; therefore, the results reflected real-life conditions. We found that less gum bleeding was experienced by people in the b0240GC group than those in the placebo group at the end of the study, and their gums appeared healthier overall. These findings suggest that b0240GC is helpful for safely improving gum health in daily life.
