2026-05-20 国立健康危機管理研究機構,理化学研究所
【TMPRSS2はウイルス侵入を促進し、感染性ウイルス粒子産生は抑制する】
＜関連情報＞
- https://www.jihs.go.jp/content4/pressrelease/2026/20260519131603.html
- https://www.jihs.go.jp/content4/pressrelease/2026/2026020/atarasikuakiraka.pdf
- https://link.springer.com/article/10.1038/s44319-026-00797-2
TMPRSS2誘導性ゴルジ体破壊は、ウイルスエンベロープ糖タンパク質のビリオンへの組み込みを制限する TMPRSS2-induced Golgi disruption restricts the incorporation of virus envelope glycoproteins into virions
Sayuri Seki,Shigeyoshi Harada,Akiko Sugimoto-Ishige,Midori Unno,Machie Sakuma,Shinsuke Ito,Hiroyuki Yamamoto,Aki Tanabe,Saori Matsuoka,Chieko Makino-Okamura,Sewon Ki,Hidehiro Fukuyama,Michishige Harada,Kazuya Tsumagari,Koshi Imami,Takashi Saito,Masato Kubo,Tadaki Suzuki,Haruhiko Koseki,Tetsuro Matano & Kosuke Miyauchi
EMBO Reports Published:19 May 2026
DOI:https://doi.org/10.1038/s44319-026-00797-2
Abstract
Understanding the relationship between viral proteins and host factors is essential for developing strategies to control virus infections. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells using angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) as viral receptor and priming protease during the viral entry phase. Here, we report that TMPRSS2 reduces the infectivity of SARS-CoV-2 and HIV-1 during the viral production phase. Treatment of virus-producing cells with a TMPRSS2 inhibitor increases the production of infectious virions. TMPRSS2 enzymatic activity specifically disrupts the trans-Golgi by phosphorylating Golgi stacking proteins through ERK activation, which disturbs virion spike incorporation and structural maturation of the viral envelope glycoproteins, causing lower viral infectivity. We find that SARS-CoV-2 envelope protein (E protein) counteracts this TMPRSS2 activity to rescue SARS-CoV-2-S incorporation. These results demonstrate negative regulation of viral envelope glycoprotein incorporation by TMPRSS2 and reveal that SARS-CoV-2 regulates the Golgi system to create an optimal viral replication environment.
