2026-10-19 東北大学
図1. 父親の高齢化に伴うマウス胎仔の脳の遺伝子発現変化と雌雄差
＜関連情報＞
- https://www.tohoku.ac.jp/japanese/2026/10/press20261019-02-telencephalon.html
- https://www.nature.com/articles/s41597-026-08446-y
マウス胚終脳のトランスクリプトームデータセットによる、父親の高齢化が性別依存的に及ぼす影響の解明 A Transcriptomic Dataset of Embryonic Mouse Telencephalon Revealing Sex-dependent Effects of Advanced Paternal Age
Haruka Endo, Takako Kikkawa & Noriko Osumi
Scientific Data Published:08 October 2026
DOI:https://doi.org/10.1038/s41597-026-08446-y Early provide
Abstract
Advanced paternal age is a recognized risk factor for autism spectrum disorder (ASD), yet the molecular mechanisms linking paternal aging to early neurodevelopment remain poorly understood. Although ASD exhibits marked sex differences in prevalence and clinical presentation, whether paternal aging exerts sex-dependent effects on the embryonic brain has not been fully examined. Here, we generated a bulk RNA-sequencing dataset from embryonic day 14.5 mouse telencephalon derived from young (3-month-old) and aged (19-month-old) fathers. To minimize variability arising from developmental asynchrony, embryonic stages were rigorously matched using a hindlimb-based morphological staging method. Principal component analysis and hierarchical clustering revealed transcriptomic variation associated with both paternal age and sex. Notably, transcriptomic profiles of female aged father-derived embryos formed a distinct cluster and showed a tendency toward increased gene expression, suggesting a sex-biased transcriptional response to paternal aging. This dataset provides a well-controlled transcriptomic resource for investigating how paternal aging influences early brain development in a sex-dependent manner.
