2023-06-22 カリフォルニア工科大学(Caltech)
◆このセンサーにより、より侵襲性の少ない血液検査を必要とせずに、患者や医療専門家は健康状態を監視することが容易になります。センサーはレーザー刻印されたグラフェンを基に構築されており、金ナノ粒子と抗体を使用してCRPを検出します。研究者たちは、今後は他の重要なタンパク質やホルモン分子のモニタリングにもこのプラットフォームを応用し、慢性疾患管理に役立てたいとしています。
<関連情報>
- https://www.caltech.edu/about/news/wearable-sweat-sensor-detects-molecular-hallmark-of-inflammation
- https://www.nature.com/articles/s41551-023-01059-5
汗中のC反応性タンパク質をモニタリングするワイヤレスパッチ A wireless patch for the monitoring of C-reactive protein in sweat
Jiaobing Tu,Jihong Min,Yu Song,Changhao Xu,Jiahong Li,Jeff Moore,Justin Hanson,Erin Hu,Tanyalak Parimon,Ting-Yu Wang,Elham Davoodi,Tsui-Fen Chou,Peter Chen,Jeffrey J. Hsu,Harry B. Rossiter & Wei Gao
Nature Biomedical Engineering Published:22 June 2023
DOI:https://doi.org/10.1038/s41551-023-01059-5
Abstract
The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein’s levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.
