2023-09-08 エディンバラ大学
◆早期発症がんの率は北アメリカ、オーストララシア、西ヨーロッパで高く、今後も増加が予測されています。増加要因については詳細な研究が必要であり、環境要因やスクリーニングの影響も不明確です。研究はエジンバラ大学と中国の浙江大学医学院の科学者によって行われ、早期発症がんの要因解明に向けた研究への支援が必要と訴えています。
<関連情報>
- https://www.ed.ac.uk/news/2023/global-surge-in-cancer-cases-among-under-50s
- https://bmjoncology.bmj.com/content/2/1/e000049
1990年から2019年までの早期発症がんの罹患率、死亡率、負担、危険因子の世界的傾向 Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019
Jianhui Zhao,Liying Xu,Jing Sun,Mingyang Song,Lijuan Wang,Shuai Yuan,Yingshuang Zhu,Zhengwei Wan,Susanna Larsson,Konstantinos Tsilidis,Malcolm Dunlop,Harry Campbell,Igor Rudan,Peige Song,Evropi Theodoratou,Kefeng Ding and Xue Li
BMJ Oncology Published:September 5, 2023
DOI: 10.1136/bmjonc-2023-000049
Abstract
Objective This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid.
Methods and analysis Incidence, deaths, disability-adjusted life years (DALYs) and risk factors for 29 early-onset cancer groups were obtained from GBD.
Results Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle Sociodemographic Index (SDI) regions had the highest burden of early-onset cancer. The morbidity of early-onset cancer increased with the SDI, and the mortality rate decreased considerably when SDI increased from 0.7 to 1. The projections indicated that the global number of incidence and deaths of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers.
Conclusion Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.
