2026-07-11 名古屋大学,科学技術振興機構
図：治療用ナノ粒子を局所送達する生体吸収性ナノファイバーシート
＜関連情報＞
- https://www.jst.go.jp/pr/announce/20260711-2/index.html
- https://www.jst.go.jp/pr/announce/20260711-2/pdf/20260711-2.pdf
- https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(26)00324-3
治療用小胞の局所的かつ持続的な送達のための生体吸収性ナノファイバーシート Bioabsorbable nanofiber sheets for localized and sustained delivery of therapeutic vesicles
Kazuhiro Suzuki ∙ Akira Yokoi ∙ Shota Kawaguchi ∙ … ∙ Hirotaka Koga ∙ Hiroaki Kajiyama ∙ Takao Yasui
Cell Reports Physical Science Published:July 10, 2026
DOI:https://doi.org/10.1016/j.xcrp.2026.103418
Highlights
- Bioabsorbable nanofiber sheets enable localized and sustained LNP delivery
- Capillary-driven fiber closure physically entraps nanoparticles within sheets
- BNF sheets provide site-specific LNP retention and complete bioabsorption
Summary
Targeted drug delivery remains a major challenge in cancer therapy, as systemic administration often causes off-target toxicity and insufficient drug exposure at disease sites. Although lipid nanoparticles (LNPs) enhance drug stability and circulation, their systemic use frequently results in limited tumor accumulation. Here, we present bioabsorbable nanofiber (BNF) sheets as a localized, biodegradable platform for sustained LNP delivery. BNF sheets entrap LNPs within their fibrous matrix through capillary-driven closure during drying and release them upon rehydration, enabling spatially confined therapeutic exposure. In a murine ovarian cancer peritoneal dissemination model, BNF sheets loaded with carboplatin-encapsulated LNPs achieved effective local tumor suppression with minimal systemic toxicity, while confirming localized LNP distribution and complete bioabsorption. This approach integrates the molecular versatility of LNPs with site-specific administration, addressing key limitations of systemic nanomedicine. This platform effectively bridges systemic nanomedicine and localized therapy, offering a clinically translatable approach for precision drug delivery.
