2026-07-11 量子科学技術研究開発機構
図１．概要説明図
＜関連情報＞
進行性核上性麻痺におけるタウ蓄積に起因する認知症状に対する遠隔ネットワーク Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy
Yuki Hori, Hironobu Endo, Kenji Tagai, Yuko Kataoka, […] , and Toshiyuki Hirabayashi
Science Advances Published:10 Jul 2026
DOI:https://doi.org/10.1126/sciadv.aed0348
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with motor and cognitive impairments. Whereas motor symptoms are associated with subcortical tau deposits, the mechanisms underlying the cognitive symptoms remain unclear due to heterogeneous and primarily subcortical distribution of pathological tau deposits. Here, we combined tau-PET (tau positron emission tomography) using a high-contrast probe we developed with a normative connectome in 37 patients with PSP and 48 healthy controls. We found that tau deposition sites functionally connected to a common cortical network that could not be derived from atrophy. This network predominantly overlapped with canonical action-mode and frontoparietal networks, which support adaptive, goal-directed behavior. Whereas the extent of primary tau deposition predicted motor symptoms, the normative connectivity strength from tau deposition sites to the identified cortical network explained the severity of cognitive deficits. These findings suggest a previously unknown mechanism that cognitive, but not motor, deficits in PSP arise from remote effects of tau deposition—independent of atrophy—via convergent connectivity to a common cortical network.
