2026-10-02 理化学研究所,大阪公立大学,慶應義塾大学先端生命科学研究所
本研究で特定した細菌叢シフトの概要
＜関連情報＞
- https://www.riken.jp/press/2026/20261002_2/index.html
- https://www.nature.com/articles/s41598-026-71455-9
肝疾患の進行に伴う主要な微生物叢の変化は、宿主環境と微生物群集を結びつける重要な分類群によって媒介される Major microbiota transitions across liver disease progression are mediated by key taxa linking host environments and microbial communities
Kenta Suzuki, Tomonori Kamiya, Hideki Fujii, Sotaro Takano, Yoshimi Yukawa-Muto, Norifumi Kawada, Shinji Fukuda, Hiroshi Masuya & Naoko Ohtani
Scientific Reports Published:25 September 2026
DOI:https://doi.org/10.1038/s41598-026-71455-9 Early provide
Abstract
The gut microbiome plays a critical role in chronic liver disease, yet quantitative methods that integrate microbial community structure with clinical indices remain limited. Here, we applied an energy landscape analysis (ELA)-based framework to characterize transitions in gut microbiota along a clinical gradient of liver disease severity, as measured by the FibroScan-AST (FAST) score. The analysis revealed characteristic community states corresponding to low, intermediate, and high FAST scores, indicating that liver disease progression is associated with structured transitions in microbial community organization rather than simple changes in overall diversity. To further dissect community-level organization, we developed the community shaping index (CSI), which quantifies how strongly individual taxa are associated with specific community structures. Integrating CSI with species–environment association parameters identified key taxa with distinct ecological roles, including unclassified Subdoligranulum taxon, an unclassified Ruminococcus gnavus group taxon, and Streptococcus salivarius, that link host environmental conditions with community composition. Exploratory causal discovery suggested that Streptococcus salivarius and the unclassified Subdoligranulum may play distinct, potentially active roles in linking liver health with gut microbial organization, but with contrasting associations: S. salivarius was linked to disease-related liver deterioration and dysbiotic states, whereas the unclassified Subdoligranulum was associated with healthier liver function and coherent community organization. Overall, this ecologically grounded framework provides a unified and mechanistic foundation for analyzing microbiome structure and disease-associated transitions.
