2026-06-02 京都大学
＜関連情報＞
- https://www.kyoto-u.ac.jp/ja/research-news/2026-06-02-1
- https://onlinelibrary.wiley.com/doi/10.1111/trf.70286
健康なドナーからの同種末梢血幹細胞採取におけるペグフィルグラスチムの有用性 Usefulness of pegfilgrastim for allogeneic peripheral blood stem cell collection from healthy donors
Tomoshige Shimizu, Tomoyasu Jo, Noriyoshi Yoshinaga, Takashi Sakamoto, Hiroyuki Matsui, Toshio Kitawaki, Junya Kanda, Momoko Nishikori, Kouhei Yamashita, Miki Nagao, …
Transfusion Published: 29 May 2026
DOI:https://doi.org/10.1111/trf.70286
Abstract
Background
Granulocyte colony-stimulating factor (G-CSF)-based mobilization is essential for peripheral blood stem cell (PBSC) collection for allogeneic transplantation. Conventional daily G-CSF requires repeated dosing and dose adjustment and often necessitates leukapheresis over multiple consecutive days, increasing donor burden. Single-dose pegfilgrastim has emerged as an alternative; however, real-world data on its impact on CD34+ cell collection in healthy donors remain limited.
Study Design and Methods
Healthy related or unrelated donors who received either a single dose of pegfilgrastim or daily filgrastim and subsequently underwent PBSC collection at Kyoto University Hospital between July 2014 and September 2025 were included. CD34+ cell harvest outcomes and donor burden were compared.
Results
A total of 39 donors were analyzed (20 pegfilgrastim, 19 filgrastim), with comparable baseline characteristics. At the start of leukapheresis, peripheral blood white blood cell counts were significantly higher in the pegfilgrastim group. Pegfilgrastim achieved greater total CD34+ cell yield (median 398.0 × 106 vs. 302.4 × 106 cells, p = .025) and higher yields per 10 L of processed blood (median 407.8 × 106 vs. 302.4 × 106 cells, p = .032). Single-session leukapheresis was more frequent with pegfilgrastim (95.0% vs. 63.2%, p = .002), and the estimated processing time required to collect 2 × 106/kg CD34+ cells was shorter (median 62.7 vs. 111.1 min, p = .040). No severe adverse events were observed.
Discussion
These findings suggest that single-dose pegfilgrastim enables more efficient PBSC collection with reduced donor burden and may represent a practical mobilization strategy in healthy allogeneic donors.
