2026-06-30 東京大学
ショウジョウバエの翅および翅を構成する細胞の模式図
＜関連情報＞
- https://www.s.u-tokyo.ac.jp/ja/press/11174/
- https://journals.biologists.com/dev/article/153/12/dev205474/372105/Cell-size-control-emerges-from-the-vein-dependent
ショウジョウバエの翅 における細胞サイズの制御は、翅脈に依存した異なる細胞群の協調的な分裂から生じる Cell size control emerges from the vein-dependent coordinated divisions of distinct cell groups in Drosophila wing
Kaoru Sugimura,Ryu Takayanagi,Toshinori Namba,Zeping Qu,Shuji Ishihara
Development Published:30 June 2026
DOI:https://doi.org/10.1242/dev.205474
ABSTRACT
During morphogenesis, cell divisions are precisely regulated in space and time. The biological objectives achieved by such regulation are not fully understood. Here, by applying a newly developed lineage-reconstruction pipeline to Drosophila pupal wing, we reveal that the wing is composed of distinct cell groups that differ in division number, timing, and spatial positioning relative to wing veins. We show that the frequencies of these lineages, together with their initial cell sizes and growth profiles, converge to achieve a highly conserved average cell size. Our data further suggest that distance from veins provides spatial information that biases where distinct lineages arise, and that loss of veins caused by perturbation of EGFR signaling suppresses a specific lineage and disrupts cell-size control. Finally, our results point to a multiscale organization of division patterns, in which vein-associated spatial information is integrated with local neighbor effects in a manner that would mitigate mechanical instability within the tissue. Together, these findings delineate a cell-size control mechanism based on coordinated divisions of distinct cell groups that supports robust morphogenesis and functional tissue design.
