2026-09-09 東京科学大学
図1. ミネラリゼーションペプチドの局在に基づいたリポソーム内金ナノ粒子合成制御の概要
＜関連情報＞
- https://www.isct.ac.jp/ja/news/m4v91cxbh4oe
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.77792
リポソームナノリアクターにおける金ナノ粒子成長のためのペプチド局在化によるナノスケール反応環境のプログラミング Programming Nanoscale Reaction Environments via Peptide Localization for Gold Nanoparticle Growth in Liposomal Nanoreactors
Yuya Abe, Joseph Fox, Zabeada Aslam, Kevin Critchley, Stephen D. Evans, Mina Okochi, Masayoshi Tanaka
Advanced Functional Materials Published: 18 August 2026
DOI:https://doi.org/10.1002/adfm.77792
ABSTRACT
Gold nanoparticles (AuNPs) exhibit size- and shape-dependent physicochemical properties, yet precise morphological control under environmentally benign conditions remains challenging due to the lack of spatial regulation of nucleation and growth. Here, we explore liposome-based nanoreactors as confined reaction fields for peptide-mediated synthesis of AuNP. Unexpectedly, biomineralization peptides that form anisotropic and faceted nanostructures in bulk solution produce distinct morphologies within liposomes, yielding highly branched Au/liposome hybrid structures. This discrepancy originates from peptide sequence–dependent spatial localization within liposomes. Peptides localized at the membrane interface induce interfacial growth, whereas internally confined peptides promote nucleation within a diffusion-restricted environment, resulting in spherical nanoparticles. Modulation of membrane composition enables switching of peptide localization, confirming that spatial positioning governs nanoparticle growth. These findings demonstrate that peptide localization acts as a molecular switch governing nanoparticle growth within liposomal nanoreactors.
