ローゼル植物に含まれる抗酸化物質には抗肥満作用があり、現在の体重管理薬に代わる食品に役立つ可能性があることが、新しい研究で明らかになりました。 Antioxidants in the roselle plant have anti-obesity properties that could help in food alternatives to current weight management medications, according to new research.
2023-03-07 ロイヤルメルボルン工科大学(RMIT)
フェノールエキスは、脂肪細胞の形成を妨げる健康食品の作成に役立つ可能性があるとされ、オーリスタットやリラグルチドのような肥満治療薬の副作用を回避することができるという。
フェノールエキスは、オリーブオイルやグリーンティーなどの植物由来のポリフェノールであり、脂肪を小さなフラクションに分解する消化酵素リパーゼを阻害することがわかった。研究チームは、フェノールエキスをビーズ状にカプセル化して、健康食品製品に使用することを計画している
<関連情報>
- https://www.rmit.edu.au/news/all-news/2023/mar/roselle
- https://ifst.onlinelibrary.wiley.com/doi/full/10.1111/ijfs.16269
Hibiscus sabdariffaのフェノール抽出物とヒドロキシクエン酸カリウムが脂肪生成に与える影響:細胞研究 Impact of phenolic extracts and potassium hydroxycitrate of Hibiscus sabdariffa on adipogenesis: a cellular study
Manisha Singh, Thilini Thrimawithana, Ravi Shukla, Charles Stephen Brennan, Benu Adhikari
International Journal of Food Science & Technology Published: 23 December 2022
DOI:https://doi.org/10.1111/ijfs.16269
Summary
Adipogenesis is a complex physiological process involving the formation of adipocytes and accumulation as adipose tissues. It is one of the contributors for the development of obesity. This study assessed the potential of phenolic extracts and potassium hydroxycitrate, obtained from Hibiscus sabdariffa, to inhibit adipogenesis. The phenolic extracts were obtained using organic solvents (methanol, ethanol and ethyl acetate) and water individually. Human adipose-derived stem cells (hADSCs) were selected to study the impact of these extracts on adipogenesis. Results showed that phenolic extracts were able to reduce lipid accumulation by about 95% in hADSCs, while potassium hydroxycitrate did not show any reduction. All the phenolic extracts downregulated the gene expression of two key adipogenic markers (PPAR-γ and aP2). Ethanol extracts exhibited the highest downregulation of PPAR-γ and aP2 by 3 and 10 times, respectively. There was no improvement in the anti-adipogenic potential when the phenolic extract was combined with potassium hydroxycitrate confirming that phenolic compounds were responsible for the inhibition of adipogenesis. These results indicate that phenolic extracts from H. sabdariffa have potential to regulate the expression of adipogenic genes and restrict the lipid accumulation in mature adipocytes. Thus, phenolic extracts can be used in formulations intended to manage obesity.
