2026-05-26 ニューヨーク大学（NYU）
Left: The rod-shaped bacterium B. subtilis under the microscope. Right: B. subtilis loses its rod shape when wall teichoic acids are depleted. Photo credits: Felix Barber, NYU/OSU and Jason Yin, NYU Langone Microscopy
＜関連情報＞
- https://www.nyu.edu/about/news-publications/news/2026/may/bacteria-wall-teichoic-acids.html
- https://www.nature.com/articles/s41564-026-02368-6
枯草菌の桿菌形態を維持するために、細胞壁のテイコ酸がペプチドグリカン合成を調節する Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis
Felix Barber,Zarina Akbary,Zhe Yuan,Jacob Biboy,Waldemar Vollmer & Enrique R. Rojas
Nature Microbiology Published:26 May 2026
DOI:https://doi.org/10.1038/s41564-026-02368-6
Abstract
Rod-shaped bacteria such as Bacillus subtilis achieve their shape by using Rod complexes to synthesize anisotropic peptidoglycan and by limiting isotropic peptidoglycan synthesis by PBP1. Wall teichoic acids are also required for rod shape, but their role is unclear. Here we use single-cell microfluidics and microscopy to show that wall teichoic acids promote rod shape by preventing the formation of nanoscopic pores in the B. subtilis cell wall. Wall teichoic acid depletion led to pore formation within minutes, coinciding with a rapid increase in PBP1-mediated peptidoglycan synthesis, which became essential for growth, and transient arrest of Rod complexes before the onset of amorphous growth. A synthetically lethal cell wall hydrolase, LytE, also became essential during wall teichoic acid depletion, meaning that PBP1 and LytE cooperatively execute amorphous growth in the absence of teichoic acids. Our results show that wall teichoic acids maintain cell shape by preventing cell wall pore formation, thereby promoting Rod complex activity and preventing PBP1 activity.
