2026-07-08 コペンハーゲン大学（UCPH）
＜関連情報＞
- https://news.ku.dk/all_news/2026/07/exercise-improves-cardiovascular-health-more-than-weight-loss-medication-after-weight-loss/
- https://www.nature.com/articles/s42255-026-01554-4
減量維持期における運動とリラグルチドが血管の健康と炎症に及ぼす影響：S-LiTE試験の事前規定二次解析 Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial
Rasmus Michael Sandsdal,Joachim Holt,Haithem Ghalib Ali Alkhefagie,Julie Rehné Jørgensen,Christian Rimer Juhl,Lisa M. Olsen,Sarah Byberg,Roopameera Thirumathyam,Lasse Gliemann,Bente Stallknecht,Jens Juul Holst,Jens Dahlgaard Hove,Thomas Bandholm,Kirstine Nyvold Bojsen-Møller,Sten Madsbad,Joachim Størling,Else Marie Bladbjerg,Charalambos Antoniades,Simon Birk Kjær Jensen & Signe Sørensen Torekov
Nature Metabolism Published:24 June 2026
DOI:https://doi.org/10.1038/s42255-026-01554-4
Abstract
Obesity and inactivity are linked to endothelial dysfunction and atherosclerosis. In this secondary analysis of the S-LiTE trial (ClinicalTrials.gov identifier: NCT04122716; EudraCT identifier: 2015–005585-32), 130 adults with obesity completed a diet-induced weight loss plan, followed by randomization to weight maintenance with exercise and/or liraglutide for 52 weeks. We show that exercise, alone or in combination with liraglutide, reduces carotid intima-media thickness and systemic pro-inflammatory cytokine levels (interleukin-6 and interferon-γ). Combination treatment also improves endothelial function biomarkers (sICAM-1, sVCAM-1 and tPA). Liraglutide alone shows no such improvements. Overall, regular physical activity, with or without GLP-1R agonists, is essential for promoting vascular health in adults with obesity.
