2026-07-22 東京大学
本研究の背景・成果・応用展開
＜関連情報＞
細胞外小胞の表面工学による超同種標的化 Super homotypic targeting by surface engineering of extracellular vesicles
Huai-Song Wang,Tianben Ding,Yuhong Liu,Fabio Lisi,Yuqi Zhou,Yaqi Zhao,Xin-Yuan Hu,Zi-Wei Yang,Jing-Lian Su,Mika Hayashi,Natsumi Tiffany Ishii,Hiroki Matsumura,Anel Umirbaeva,Hongwei Guo,Yin-Yu Yan,Fu-Han Gao,Jia-Jing Li,Yasutaka Kitahama,Petra Paiè,Ayumi Taguchi,Kenbun Sone,Yuka Inoue,Takayuki Ueno,Abdullah N. Alodhayb,… Keisuke Goda
Nature Biomedical Engineering Published:22 July 2026
DOI:https://doi.org/10.1038/s41551-026-01743-2
Abstract
Homotypic targeting is the inherent ability of cells to preferentially interact with cells of the same type, a phenomenon seen in cell adhesion, tissue formation and immune responses. However, its potential remains underexploited. Here we report a strategy to substantially enhance homotypic targeting through extracellular vesicles secreted by cells. By engineering the surface of small extracellular vesicles (sEVs) with lanthanides, we amplify specific cell–sEV interactions by more than 25-fold, enabling the selective capture of sEVs by cells of the same lineage even in the presence of excess off-target sEVs. We term this effect ‘super homotypic targeting’. Super homotypic targeting provides a means to distinguish sEVs of different origins within highly heterogeneous sEV populations and enables two applications: using cells to detect specific sEVs and using sEVs to detect specific cells, specifically demonstrated here in the context of cancer detection from blood samples. Super homotypic targeting could hold potential for diagnostics, immunotherapy, drug delivery, rejuvenation and tissue engineering.
