2026-08-06 ミュンヘン大学（LMU）
＜関連情報＞
- https://www.lmu.de/en/newsroom/news-overview/news/chronobiology-setting-time-in-organs-8a00f1b3.html
- https://www.nature.com/articles/s41556-026-02041-4
CLOCK/BMAL1相互作用ネットワークにより、組織調節因子としてのホメオドメイン因子が明らかになった CLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators
Fatih Aygenli,Lukas A. Huschet,Tanja Popp,Andrea Ribeiro,Darina Barkhatova,Céline Jouffe,Ricardo Trozzo,Jerome S. Menet,Roland Rad,Kenneth A. Dyar,Maciej Lech,Tobias Straub,Alicia K. Michael & Maria S. Robles
Nature Cell Biology Published:06 August 2026
DOI:https://doi.org/10.1038/s41556-026-02041-4
Abstract
Circadian clocks underlie daily rhythms in physiology by coordinating temporal patterns of gene expression and protein function throughout the body. At the core of this system in mammals is CLOCK/BMAL1, a ubiquitously expressed heterodimeric transcription factor complex that orchestrates tissue-specific circadian gene expression. The basis for this specificity remains unclear, but tissue-specific interactions at chromatin could provide one. Here we used chromatin immunoprecipitation coupled to mass spectrometry to map CLOCK/BMAL1-associated protein complexes on chromatin in mouse liver, kidney and lung. We detected 1,510 associated proteins, most of which were tissue-specific and not explained by protein abundance. Among these, we identified the homeodomain transcription factors PROX1, HNF1B and HOXA5 as tissue-enriched interactors that bind BMAL1, co-occupy most BMAL1 genomic sites and establish organ-restricted circadian transcription. Our findings demonstrate that tissue-specific transcription factors confer cellular identity on the core clock, thereby contributing to organ-specific patterns of rhythmic gene expression.
