永遠の化学物質の混合物としての毒性研究(It all adds up: Study finds forever chemicals are more toxic as mixtures)

2024-10-01 バッファロー大学(UB)

<関連情報>

• https://www.buffalo.edu/news/releases/2024/10/study-finds-forever-chemicals-are-more-toxic-as-mixtures.html
• https://pubs.acs.org/doi/10.1021/acs.est.4c06017

パーフルオロアルキル物質(PFAS)の混合物の環境およびヒト血中濃度における神経毒性効果 Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations

Karla M. Ríos-Bonilla,Diana S. Aga,Jungeun Lee,Maria König,Weiping Qin,Judith R. Cristobal,Gunes Ekin Atilla-Gokcumen,and Beate I. Escher
Environmental Science & Technology  Published:September 11, 2024
DOI:https://doi.org/10.1021/acs.est.4c06017

Abstract

Per- and polyfluoroalkyl substances (PFAS) may cause various deleterious health effects. Epidemiological studies have demonstrated associations between PFAS exposure and adverse neurodevelopmental outcomes. The cytotoxicity, neurotoxicity, and mitochondrial toxicity of up to 12 PFAS including perfluoroalkyl carboxylates, perfluoroalkyl sulfonates, 6:2 fluorotelomer sulfonic acid (6:2 FTSA), and hexafluoropropylene oxide-dimer acid (HPFO-DA) were tested at concentrations typically observed in the environment (e.g., wastewater, biosolids) and in human blood using high-throughput in vitro assays. The cytotoxicity of all individual PFAS was classified as baseline toxicity, for which prediction models based on partition constants of PFAS between biomembrane lipids and water exist. No inhibition of the mitochondrial membrane potential and activation of oxidative stress response were observed below the cytotoxic concentrations of any PFAS tested. All mixture components and the designed mixtures inhibited the neurite outgrowth in differentiated neuronal cells derived from the SH-SY5Y cell line at concentrations around or below cytotoxicity. All designed mixtures acted according to concentration addition at low effect and concentration levels for cytotoxicity and neurotoxicity. The mixture effects were predictable from the experimental single compounds’ concentration–response curves. These findings have important implications for the mixture risk assessment of PFAS.