2025-06-26 東京大学
多価不飽和脂肪酸の完全固相合成
<関連情報>
- https://www.t.u-tokyo.ac.jp/press/pr2025-06-26-001
- https://www.t.u-tokyo.ac.jp/hubfs/press-release/2025/0626/001/text.pdf
- https://www.nature.com/articles/s41557-025-01853-5
完全固相合成による多価不飽和脂肪酸および生体機能性類似体への迅速なアクセス Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis
Yutaro Saito,Mayuko Akita,Azusa Saika,Yusuke Sano,Masashi Hotta,Jumpei Morimoto,Akiharu Uwamizu,Junken Aoki,Takahiro Nagatake,Jun Kunisawa & Shinsuke Sando
Nature Chemistry Published:25 June 2025
DOI:https://doi.org/10.1038/s41557-025-01853-5
Abstract
Polyunsaturated fatty acids (PUFAs) represent a fundamental and essential class of lipids that exhibit versatile biofunctions. Lipidomic analysis has identified a growing number of lipid species, including PUFAs with diverse structural variations and biofunctions, yet their structure–function relationships are still largely unknown. In this context, an efficient synthesis of PUFAs would be highly desirable. However, no practical methodology exists for their preparation, in contrast to peptides and nucleic acids, for which diverse molecules are accessible through a well-established solid-phase synthesis. To address this, we have developed an efficient and expedited method to access a wide array of PUFAs by full solid-phase synthesis. The method allows the synthesis of various PUFAs and analogues through rapid and facile operations. Moreover, within our PUFA library, we have discovered an artificial fatty acid, antiefin, that has a high anti-inflammatory effect in vivo. Therefore, our practical synthetic pathway to PUFAs, a crucial class of lipids, is expected to make an important contribution to lipid science.
