2025-11-26 ブラウン大学
<関連情報>
- https://www.brown.edu/news/2025-11-26/rsv-urban-rural-immunization
- https://www.science.org/doi/10.1126/sciadv.ady5457
都市部の接触パターンがRSウイルスの流行を形作り、ワクチン接種に影響を与える Urban contact patterns shape respiratory syncytial virus epidemics with implications for vaccination
Presley Kimball, Jean-Sebastien Casalegno, Pamela P. Martinez, Ayesha S. Mahmud, […] , and Rachel E. Baker
Science Advances Published:26 Nov 2025
DOI:https://doi.org/10.1126/sciadv.ady5457
Abstract
Urban environments may alter the landscape of disease transmission with implications for control. Yet, it is unclear whether urban-rural differences exist in the dynamics of childhood respiratory diseases, given specific mixing patterns in younger age groups. Here, we leverage county-level data on respiratory syncytial virus (RSV) from the United States to reveal an urban-rural gradient in both the intensity and age structure of the RSV epidemic, where urban locations experience more prolonged epidemics with higher burden in infants (under 1 year of age). We develop a mechanistic epidemiological model to show that these differences can be explained by daycare utilization rates in children under 5. Using our model to consider control measures, we find that expanding seasonal immunization access in urban and rural areas may limit the risk of off season RSV epidemics.
