2026-02-25 株式会社オーガンテック
成体由来3種幹細胞から再生した毛包より生体外で成長した髪の毛
＜関連情報＞
- https://prtimes.jp/main/html/rd/p/000000015.000116188.html
- file:///C:/Users/81805/Downloads/d116188-15-1fb73a3781f9bf711793cb74dd818f21.pdf
- https://www.sciencedirect.com/science/article/pii/S0006291X26002238
体外培養システムにおいて、器官誘導能を持つ幹細胞と補助間葉系細胞集団を用いた、完全に機能する毛包器官の再生 Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system
Koh-ei Toyoshima, Ayako Tsuchiya, Miho Ogawa, Miki Takase, Tarou Irié, Masayuki Yanagisawa, Richard H. Kaszynski, Hiroshi Fujimaki, Kyoko Baba, Takayuki Sugimoto, Akira Takeda, Akio Sato, Takashi Tsuji
Biochemical and Biophysical Research Communications Available online: 20 February 2026
DOI:https://doi.org/10.1016/j.bbrc.2026.153459
Highlights
- We found PDGFRa+/Sca1+/CD34+ mesenchymal cells supporting in vitro hair regeneration.
- PDGFRa+/Sca1+/CD34+ cells originate from the peri-bulge region of adult hair follicles.
- Adult bioengineered hair follicle germs restore full functions, including follicular downgrowth.
Abstract
Organ morphogenesis is essential for not only integrated organ functions in the body but also the determination of adult-tissue stem cells and their niche. Only hair follicle organs can cyclically regenerate in the variable bulbous germinative region as a form of programmed organ regeneration in adults. Here, we identified a cell population, hair follicle organ-intrinsic mesenchymal cells, with PDGFRα+/Sca1+/CD34high+ mesenchymal cells, from the boundary zone of the epithelial stem cell niche by using the organ germ method, which plays essential roles in entering and promoting the downgrowth phase of the hair cycle. The bioengineered hair follicle germ reconstituted from bulge region-derived epithelial stem cells, dermal papillae and mesenchymal cells has full functions, including downgrowth, full-size hair follicle regeneration and the hair cycle, both in in vitro artificial skin and after intracutaneous skin transplantation. This study provides significant contributions to the basic and medical science of adult organ-inductive potential stem cells and their niches in organ morphogenesis and the adult hair cycle.
