2026-06-19 理化学研究所,東京医科大学
抗原提示細胞に介入し制御性T細胞を増やす（赤矢印は増えることを意味）方法を開発
＜関連情報＞
- https://www.riken.jp/press/2026/20260619_1/index.html
- https://www.nature.com/articles/s41590-026-02566-8
Runx–CBFβは、免疫寛容性Thetis細胞の発達を制御する Rung–CBFβ regulates the development of tolerogenic Thetis cells
Chihiro Ogawa,Chengcheng Zou,Yoselin A. Paucar Iza,Motoi Yamashita,Tyler Park,Junji Harada,Naoko Satoh-Takayama,Masahiko Kuroda,Chrysothemis C. Brown & Ichiro Taniuchi
Nature Immunology Published:19 June 2026
DOI:https://doi.org/10.1038/s41590-026-02566-8
Abstract
Peripherally induced regulatory T (pTreg) cells play an essential role in establishing immune tolerance to gut microbiota and food antigens. A subset of RORγt-expressing antigen-presenting cells, Thetis cell subset IV (TC IV), plays an essential role in intestinal tolerance. However, the transcription factors governing the differentiation of this subset remain unclear. Here we show that Runx–CBFβ complexes regulate the development of specific TC subsets. Mice lacking CBFβ2 exhibited loss of TC II, III and IV, with loss of RORγt+ pTreg cells. Transgenic CBFβ2 expression by Cd11c-Cre restored TC IV and RORγt+ pTreg cell differentiation in CBFβ2-deficient mice. Conditional inactivation of Runx1 and Runx3 by Cd11c-Cre selectively impaired TC III and IV. Conversely Cd11c-Cre-driven transgenic Runx expression enhanced TC IV differentiation and thus RORγt+ pTreg cell induction. These findings establish a critical pathway for TC IV differentiation and provide new insights into therapeutic interventions to promote RORγt+ pTreg cell induction in autoimmune diseases.
