2023-06-21 ノースカロライナ州立大学(NCState)
◆犬は主に長鎖PFASのPFOSが検出され、馬は他の環境汚染源からの暴露が示唆されました。獣医学的な血液検査では、肝臓と腎臓の機能に影響を及ぼす診断バイオマーカーの変化が観察されました。犬は家庭内の監視役として重要であり、PFASは井戸水以外の家庭内の別の汚染源からの暴露を示唆しています。この研究は、環境科学と技術の誌に掲載され、国立環境衛生科学研究所とノースカロライナポリシーコラボラトリーの支援を受けて行われました。
<関連情報>
- https://news.ncsu.edu/2023/06/pfas-found-in-blood-of-dogs-horses-living-near-fayetteville-n-c/
- https://pubs.acs.org/doi/full/10.1021/acs.est.3c01146
ノースカロライナ州グレイズクリークにおけるパーフルオロアルキル物質およびポリフルオロアルキル物質への曝露と関連する健康バイオマーカーの監視役としての家庭犬および馬 Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina
Kylie D. Rock, Madison E. Polera, Theresa C. Guillette, Hannah M. Starnes, Kentley Dean, Mike Watters, Debra Stevens-Stewart, and Scott M. Belcher
Environmental Science and Technology Published:June 20, 2023
DOI:https://doi.org/10.1021/acs.est.3c01146
Abstract
Central North Carolina (NC) is highly contaminated with per- and polyfluoroalkyl substances (PFAS), in part due to local fluorochemical production. Little is known about the exposure profiles and long-term health impacts for humans and animals that live in nearby communities. In this study, serum PFAS concentrations were determined using liquid chromatography high-resolution mass spectrometry and diagnostic clinical chemistry endpoints were assessed for 31 dogs and 32 horses that reside in Gray’s Creek NC at households with documented PFAS contamination in their drinking water. PFAS were detected in every sample, with 12 of the 20 PFAS detected in ≥50% of samples from each species. The average total PFAS concentrations in horses were lower compared to dogs who had higher concentrations of PFOS (dogs 2.9 ng/mL; horses 1.8 ng/mL), PFHxS (dogs 1.43 ng/mL, horses < LOD), and PFOA (dogs 0.37 ng/mL; horses 0.10 ng/mL). Regression analysis highlighted alkaline phosphatase, glucose, and globulin proteins in dogs and gamma glutamyl transferase in horses as potential biomarkers associated with PFAS exposure. Overall, the results of this study support the utility of companion animal and livestock species as sentinels of PFAS exposure differences inside and outside of the home. As in humans, renal and hepatic health in domestic animals may be sensitive to long-term PFAS exposures.
