藻類で作られた柔らかな生体材料が応力で光る(Soft, Living Materials Made With Algae Glow Under Stress)

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2023-10-23 カリフォルニア大学サンディエゴ校(UCSD)

◆カリフォルニア大学サンディエゴ校を中心に研究を行っているチームは、圧縮、伸長、ねじれなどの力に反応して光る3Dプリント材料を開発しました。この材料は、単細胞藻類であるディノフラジェレートから発光性を得ています。
◆ディノフラジェレートが圧力を受けると、これらの材料は光を放射し、その光の強度は加えられる力に応じて変化します。この材料は機械センサー、ソフトロボティクス、医療デバイスなど、さまざまな応用分野で使用される可能性があり、さらなる研究が進行中です。

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超高感度かつ堅牢な機械発光生体材料 Ultrasensitive and robust mechanoluminescent living composites

Chenghai Li ,Nico Schramma ,Zijun Wang ,Nada F. Qari ,Maziyar Jalaal,Michael I. Latz ,and Shengqiang Cai
Science Advances  Published:20 Oct 2023
DOI:https://doi.org/10.1126/sciadv.adi8643

藻類で作られた柔らかな生体材料が応力で光る(Soft, Living Materials Made With Algae Glow Under Stress)

Abstract

Mechanosensing, the transduction of extracellular mechanical stimuli into intracellular biochemical signals, is a fundamental property of living cells. However, endowing synthetic materials with mechanosensing capabilities comparable to biological levels is challenging. Here, we developed ultrasensitive and robust mechanoluminescent living composites using hydrogels embedded with dinoflagellates, unicellular microalgae with a near-instantaneous and ultrasensitive bioluminescent response to mechanical stress. Not only did embedded dinoflagellates retain their intrinsic mechanoluminescence, but with hydrophobic coatings, living composites had a lifetime of ~5 months under harsh conditions with minimal maintenance. We 3D-printed living composites into large-scale mechanoluminescent structures with high spatial resolution, and we also enhanced their mechanical properties with double-network hydrogels. We propose a counterpart mathematical model that captured experimental mechanoluminescent observations to predict mechanoluminescence based on deformation and applied stress. We also demonstrated the use of the mechanosensing composites for biomimetic soft actuators that emitted colored light upon magnetic actuation. These mechanosensing composites have substantial potential in biohybrid sensors and robotics.

生物工学一般
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