2026-08-09 中国科学院（CAS）
Figure 1. Conceptual framework of MPSS (Image by QIBEBT)
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202608/t20260810_1186981.shtml
- https://www.sciencedirect.com/science/article/pii/S0734975026002065
微生物特異的および製品特異的な、拡張可能なバイオ製造戦略 Microbe-specific and product-specific strategies for scalable biomanufacturing
Shi’’an Wang, Zhengjun Li, Peng Hu, Qiming Wang, Fang Chen, Peng Xu
Biotechnology Advances Available online: 30 July 2026
DOI:https://doi.org/10.1016/j.biotechadv.2026.109000
Highlights
- Application-oriented topic selection is addressed.
- Microbe-Specific and Product-Specific Strategies (MPSS) are introduced.
- Applied Microbial Population Biology (AMPB) is proposed.
- MPSS for End-to-End Bioprocess Compatibility is discussed.
Abstract
The translation of microbial biotechnology from laboratory research to commercial application remains a persistent challenge, despite decades of effort. A key yet often neglected issue is the misalignment between microbial host selection, product properties, and process constraints at the early stages, which often limits scalability. Here, we propose Microbe-Specific and Product-Specific Strategies (MPSS) as a conceptual framework to rationalize host–product pairing based on intrinsic microbial traits and product specifications. By incorporating Applied Microbial Population Biology (AMPB), the framework extends this rationale to the strain level, emphasizing application-oriented strain selection and engineering from the outset of a project. Together, MPSS and AMPB offer a structured approach to align early-stage laboratory research with the practical requirements of industrial biomanufacturing, enabling the development of biotechnological solutions with significant societal and economic impact.
