2024-10-23 ワシントン大学セントルイス校
<関連情報>
- https://source.washu.edu/2024/10/implantable-device-may-prevent-death-from-opioid-overdose/
- https://www.science.org/doi/10.1126/sciadv.adr3567
オピオイド過剰摂取による死亡を予防する自律型埋め込み型装置 An autonomous implantable device for the prevention of death from opioid overdose
Joanna L. Ciatti, Abraham Vázquez-Guardado, Victoria E. Brings, Jihun Park, […], and John A. Rogers
Science Advances Published:23 Oct 2024
DOI:https://doi.org/10.1126/sciadv.adr3567
Abstract
Opioid overdose accounts for nearly 75,000 deaths per year in the United States, now a leading cause of mortality among young people aged 18 to 45 years. At overdose levels, opioid-induced respiratory depression becomes fatal without the administration of naloxone within minutes. Currently, overdose survival relies on bystander intervention, requiring a nearby person to find the overdosed individual and have immediate access to naloxone to administer. To circumvent the bystander requirement, we developed the Naloximeter: a class of life-saving implantable devices that autonomously detect and treat overdose while simultaneously contacting first responders. We present three Naloximeter platforms, for fundamental research and clinical translation, all equipped with optical sensors, drug delivery mechanisms, and a supporting ecosystem of technology to counteract opioid-induced respiratory depression. In small and large animal studies, the Naloximeter rescues from otherwise fatal opioid overdose within minutes. This work introduces life-changing, clinically translatable technologies that can broadly benefit a susceptible population recovering from opioid use disorder.
