家庭用検査を可能にする小型レーザー技術を開発 (Miniature laser technology could bring lab testing into your home)

2026-03-10 チャルマース工科大学

A research team at Chalmers University of Technology, Sweden, has developed new laser technology that could lead to tiny, cost-effective biosensors. The sensors integrate lasers and optics together on a centimeter-sized chip, which could move testing from hospitals to patients’ homes. This, in turn, would free up hospital beds and reduce visits to clinics.

＜関連情報＞

• https://news.cision.com/chalmers/r/miniature-laser-technology-could-bring-lab-testing-into-your-home,c4319080
• https://pubs.acs.org/doi/10.1021/acssensors.5c01997

オンチップメタグレーティング集積レーザーを搭載したフラットプラズモニックバイオセンサー Flat Plasmonic Biosensor with an On-Chip Metagrating-Integrated Laser

Erik Strandberg,Mindaugas Juodėnas,Hana Šípová-Jungová,Mikael Käll
ACS Sensors  Published: October 8, 2025
DOI:https://doi.org/10.1021/acssensors.5c01997

Abstract

Metasurfaces are emerging as a transformative platform in optics, offering compact and versatile alternatives to bulky traditional components. Here, we present a metasurface-enabled, on-chip surface plasmon resonance (SPR) biosensor that enables label-free biomolecular analysis in a miniaturized, chip-scale format. By integrating flat metaoptics together with semiconductor lasers, a collimated fan of light for angle-resolved SPR measurements can be emitted directly into a glass substrate, eliminating the need for conventional optics. As a proof of concept, we demonstrate a bulk refractive index sensitivity of 4.9 × 10^–6 RIU, along with multiplexed detection of low-molecular-weight microRNA with limits of detection of 0.1 nM via direct sensing and 0.02 nM with antibody amplification. The scalability of metasurface fabrication, coupled with the low cost of semiconductor lasers, suggests this platform can be readily adapted for diverse sensing modalities and mass manufacture, potentially transforming SPR beyond its conventional, benchtop implementations.