2026-11-09 ケンブリッジ大学
＜関連情報＞
- https://www.cam.ac.uk/stories/treatment-promotes-repair-after-heart-attack
- https://www.nature.com/articles/s44161-026-00910-7
MycおよびサイクリンT1をコードする一過性修飾mRNAは、心筋損傷後の心機能を改善する A transient modified mRNA encoding Myc and cyclin T1 improves cardiac function after myocardial injury
Aleksandra Boikova, Gregory A. Quaife-Ryan, Christopher A. P. Batho, Rowda Dahir, Henrietta Cserne Szappanos, Harley Robinson, Elsa Lawrence, Camilla Ascanelli, Jin Seok Lee, Kypros Kyprianou Kokonos, Karin Jennbacken, Christopher R. Hunter, Patricia G. Rodrigues, Gina Hyberg, Qing-Dong Wang, Kenny M. Hansson, Adam Seaton, Maria Victoria Rodriguez Noci, Alby Biju, Silvia Da Pra, Gabriele D’Uva, Megan Bywater, Jasmin Straube, Kamil A. Sokolowski, …Catherine H. Wilson
Nature Cardiovascular Research Published:09 November 2026
DOI:https://doi.org/10.1038/s44161-026-00910-7
Abstract
Myc is an evolutionarily conserved transcription factor that is necessary for the restoration of tissues in multiple regenerative species. The adult mammalian heart lacks regenerative capacity and cardiomyocytes fail to divide following damage-induced signaling. Transgenic expression of Myc and cyclin T1 can drive substantial adult cardiomyocyte proliferation to replace lost cardiomyocytes. Here, using transgenic models and a prototypical mRNA therapeutic, we show that Myc and cyclin T1 require transient induction for cardiomyocyte proliferation that leads to myocardial repair and functional recovery after myocardial infarction in mice. This research provides a strategy to translate Myc–cyclin T1 coexpression for cardiac regeneration to address serious unmet needs in the treatment of cardiovascular disease.
