2026-06-11 イェール大学
＜関連情報＞
- https://news.yale.edu/2026/06/11/genomes-oceania-offer-new-clues-human-evolution
- https://www.science.org/doi/10.1126/science.adr6749
近オセアニアにおける機能的遺伝的多様性は、長期にわたる隔離と古代の遺伝子浸透によって形成される Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania
Patrick F. Reilly, Stephen Rong, Daniela Tejada-Martinez, Samantha L. Miller, […] , and Serena Tucci
Science Published:11 Jun 2026
DOI:https://doi.org/10.1126/science.adr6749
The complex evolutionary history of Near Oceanians.
Abstract
Near Oceanic populations harbor substantial cultural, phenotypic, and genetic diversity yet are drastically underrepresented in human genomics. We generated 177 high-coverage Near Oceanian whole genomes and analyzed them alongside 1284 worldwide genomes, revealing major distinctions among and within islands, including long-term isolation and strong population bottlenecks. We reconstructed 1.897 billion base pairs of the archaic genome, including 831.9 million base pairs of Denisovan sequence, and found evidence for introgression from three Denisovan-like groups in Near Oceanians and adaptive Denisovan introgression at TRPS1, a skeletal development gene also under selection in central African rainforest hunter-gatherers and highland Ecuadorians. We then performed a massively parallel reporter assay and discovered 3127 high-frequency introgressed expression-modulating variants, finding an enrichment of functional impacts on genes in the interferon-γ signaling pathway including JAK1, GBP2, and OAS1.
